Key Differences Between The Two Weight Loss Injections 

The biggest difference between Wegovy and Mounjaro is that they have different FDA approved (food and drug administration) uses. Wegovy is primarily a weight loss approved medication for adults and adolescents that are 12 and older. It is also approved to lower the risk of cardiovascular problems in certain adults. Wegovy on its own is not approved to treat diabetes. However, a lower dose of Wegovy that is known as Ozempic is approved to treat type 2 diabetes. 

Mounjaro at the moment is only approved as a medication to treat type 2 diabetes in adults. It works best when you also start a diabetes-friendly diet and exercise plan. You can use it on its own or with other diabetes medication as well. 

The eligibility criteria of the two medications is also different. Wegovy is for adults that are considered obese or overweight and have heart diseases. A person must have at least one weight related health condition like high cholesterol, type 2 diabetes, or high blood pressure. With Mounjaro, there is no requirement related to body weight so people that are not obese can also take this medication. 

The way they work is similar, yet different at the same time. Both these weight loss medications work by imitating incretins. Now what are Incretins? Incretins are a gut hormone that are in charge of sending signals to the pancreas to release insulin after you are done eating and in a way they communicate with the liver to produce less glucose. The effect of these medicines mimicking incretins is that you start to feel more full quickly or for a longer period of time so it can help reduce the feeling of hunger. It also helps your body to regulate blood sugar. Now the difference between Wegovy and Mounjaro is that they imitate two separate incretins. Wegovy mimics the GLP-1 receptor agonist class. Mounjari also acts like GLP-1 in the body. However it also acts like the incretin known as GIP which allows it to manage blood sugar more effectively because of its dual mimicking for people with type 2 diabetes. 

These medications also have slightly different storage requirements. Both of these can be stored in the refrigerator or at room temperature. However, Wegovy lasts longer when it is stored outside the fridge. Wegovy pens can be stored outside the fridge for up to 28 days whereas Mounjaro pens and vials can be stored outside the fridge for up to 21 days  only. 

Which One Is More Effective For Weight Loss? 

Mounjaro and Wegovy are both effective weight loss medications. But between the two, Mounjaro has shown greater weight loss results during clinical trials. In the clinical trials, on average, people with diabetes taking the highest dose of Mounjaro, a dose of 15 mg lost 15.7% of their body weight by the end of the study and almost a third of the people reported at least a 20% reduction in their overall body weight.However, the people who took the weekly maintenance dose of Wegovy in the clinical trial of 2.5 mg reported an average of

9.6% reduction in their average body weight. 

With the results of these clinical trials, it is easy to conclude that weight loss results of

Mounjaro are higher as compared to Wegovy. This makes Wegovy a better choice for people who want clear results quickly. However, if you are someone who has cardiovascular problems and wants to lose weight, then Wegovy is more beneficial for you because of its proven cardiovascular benefits which Mounjaro does not offer. In a clinical trial, Wegovy lowered the risk of major adverse cardiovascular events (MACE) by 20%. MACE includes various different things such as heart attacks, strokes, or cardiovascular death. This trial helped conclude that Wegovy can help reduce the risks of MACE for people that are obese with heart diseases.