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Mounjaro activates GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors, enhancing insulin secretion, slowing gastric emptying, and reducing appetite. This dual mechanism helps decrease calorie intake and support long-term weight management.
Clinical studies show:
Up to 22.5% weight loss in individuals using the highest dose (15mg) over 72 weeks.
91% of users lose at least 5% of their initial body weight.
Initial effects are noticeable within weeks, with significant weight loss seen over months.
First few weeks: Users often notice reduced appetite and improved portion control.
3 to 6 months: Visible weight loss is typically observed, with some users losing up to 15% of their body weight.
1 year and beyond: Continued use can lead to a total weight reduction of up to 22.5%.
Discontinuation may result in weight regain, so long-term use may be necessary for sustained results.
Treatment Progression
After 6 Months: Significant weight loss (up to 15% of initial body weight).
After 1 Year: Enhanced metabolic benefits and up to 22.5% weight loss.
After 5 Years: Long-term weight maintenance likely requires continued treatment.
Mounjaro mimics natural gut hormones that regulate food intake and energy balance.
GIP and GLP-1 receptor activation: Increases insulin release, helping to regulate blood sugar and metabolism.
Slows digestion: Prolongs the feeling of fullness, reducing calorie consumption.
Reduces food cravings: Alters hunger signals to promote mindful eating and long-term weight loss.
Mounjaro is available in multiple doses: 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, and 15mg.
Starting Dose: 2.5mg injected once weekly.
Dose Increase: After four weeks, the dose may be increased based on response, up to a maximum of 15mg per week.
Administration: Inject subcutaneously (under the skin) in the thigh, abdomen, or upper arm.
Missed Dose: If missed, take it within four days; otherwise, skip and continue as scheduled.
While Mounjaro is generally well-tolerated, some users may experience side effects.
Common Side Effects:
Uncommon Side Effects:
Most side effects are mild and diminish over time. If severe or persistent adverse effects occur, consult a healthcare professional.
Reporting Mounjaro Side Effects
Report any adverse effects to your doctor or pharmacist. In the UK, side effects can also be reported through the Yellow Card Scheme, contributing to medication safety monitoring.
Pancreatitis: Discontinue use and seek medical attention if severe abdominal pain occurs.
Hypoglycaemia: Monitor blood glucose levels, especially if taking other antidiabetic medications.
Gastrointestinal Issues: Use cautiously if you have a history of severe gastrointestinal diseases.
Pregnancy and Breastfeeding: The safety of Mounjaro during pregnancy or breastfeeding has not been established; consult your doctor before use.
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