Sildenafil functions by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which regulates blood flow in the penis. By blocking this enzyme, sildenafil enhances blood flow to the penile tissues during sexual arousal, facilitating the achievement and maintenance of an erection.
Clinical studies have demonstrated that sildenafil is effective in treating ED for many men. While the 50mg dose is commonly prescribed, the 25mg dose may be appropriate for those who experience side effects with the higher dose or have underlying health conditions. It's important to note that sildenafil requires sexual stimulation to be effective; it will not cause an erection without arousal.
Sildenafil typically begins to work within 30 to 60 minutes after ingestion. Its effects can last up to four hours, providing a window of opportunity for sexual activity. For optimal results, it's advisable to take the tablet on an empty stomach, as a heavy meal can delay its onset of action.
Recommended Dose: Take one tablet approximately one hour before planned sexual activity.
Frequency: Do not take more than one tablet in a 24-hour period.
Administration: Swallow the tablet whole with water.
Considerations: Avoid consuming large amounts of alcohol or high-fat meals before taking sildenafil, as these can reduce its effectiveness.
As with any medication, sildenafil may cause side effects, though not everyone experiences them. Common side effects include:
These side effects are usually mild and temporary. If you experience severe or persistent adverse effects, such as a prolonged erection lasting more than four hours (priapism), sudden vision loss, or chest pain, seek immediate medical attention.
Nitrate Interaction: Do not take sildenafil if you are using nitrates for chest pain, as this combination can cause a dangerous drop in blood pressure.
Medical Conditions: Consult your doctor before using sildenafil if you have heart problems, low blood pressure, or have had a recent stroke or heart attack.
Alcohol Consumption: Limit alcohol intake, as excessive drinking can impair the ability to achieve an erection and may increase the risk of side effects.
Storage: Keep sildenafil in a cool, dry place, away from direct sunlight and out of reach of children.
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